Simple stepwise route to 1-substituted 2-amino-3-ethoxycarbonylindolizines.

Abstract

2-Chloro-N-ethoxycarbonylmethylpyridinium bromide reacts with substituted acetonitriles in two steps; the initially formed pyridine anhydro baseses undergo further ring closure to 2-amino-3-ethoxycarbon-ylindolizines.