New Approach to the Synthesis of 2-Alkylsulfanyl-4,5,6-trimethylnicotinonitriles.

Abstract

Multicomponent condensation of acetaldehyde, cyanothioacetamide, 1-(but-2-en-2-yl)pyrrolidine, and alkyl halides afforded 2-alkylsulfanyl-4,5,6-trimethylnicotinonitriles. Their structure was confirmed by IR, 1H NMR spectroscopy, and chromatography-mass spectrometry.