Unexpected Formation of 6,7-Dihydrobenzo[4',5']imidazo-[1 ',2': 1,6]pyrimido[5,4-a]indolizine Derivative in the Alkylation of 2-Amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl)indolizine.

Abstract

An attempt to effect exhaustive alkylation of 2-amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl) indolizine with alkyl iodides in boiling acetone led to the formation of 6,6-dimethyl-8-(4-methoxybenzoyl)-6,7-dihydrobenzo[4',5']imidazo[1',2' : 1,6]pyrimido[5,4-a]indolizine instead of expected N-alkyl derivatives. The product structure was proved by X-ray analysis.