Synthesis of 4-Methylmorpholinium 6-Amino-3,5-dicyano- 4-(furan-2-yl)pyridine-2-thio(seleno)lates and 3-[Aryl(hetaryl)]- 2-cyanoprop-2-enethioamides by Michael Reaction.

Abstract

Michael reaction of dimethyl (furan-2-ylmethylidene)malonate with 2-cyanoethanethio(seleno)- amides and 4-methylmorpholine afforded 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine- 2-thio(seleno)lates via exchange of the CH acid components. Aryl(hetaryl)methylidenemalononitriles reacted with cyanoethanethioamide under analogous conditions to give 3-aryl(hetaryl)-2-cyanoprop-2-enethioamide which were converted into 3-aryl(hetaryl)-2-(1,3-thiazol-2-yl)prop-2-enenitriles according to Hantzsch.