Synthesis of 2-Thioxo-4,6-diphenyl-1,2-dihydronicotinonitrile via Condensation of Benzaldehyde with Cyanothioacetamide and p-(1-Styryl)morpholine.

Abstract

2-Thioxo-4,6-diphenyl-1,2-dihydronicotinonitrile has been prepared via condensation of benzaldehyde with cyanothioacetamide and N-(1-styryl)morpholine; alkylation of the product with alkyl halides has afforded substituted 2-alkylsulfanyl-4,6-diphenylnicotinonitriles and 3-amino-2-acyl-4,6-diphenylthieno[2,3-b]pyridines.